A study has found that gut bacteria metabolites affect the brain in Alzheimer’s disease.
The study, which used artificial intelligence to investigate the reaction of brain receptors to the metabolites of gut bacteria in Alzheimer’s disease, was published in Cell Reports.
The gut-brain axis, linked to the gut microbiome, provides clues to the causes and treatments of various diseases. Gut bacteria produce specific metabolites, and analyzing these metabolites can reveal various biochemical pathways related to the gut-brain axis.
Previous studies have linked Alzheimer’s disease to changes in the gut microbiome, as the gut’s immune function affects the brain. Therefore, if we can prevent the metabolites of gut bacteria from binding to specific receptors in the brain, we can reduce the risk of Alzheimer’s disease. Machine learning has been used to reveal and predict the corresponding relationship between these metabolites and brain receptors.
The researchers used artificial intelligence (AI) to investigate the association between 408 brain receptors and the metabolites of gut bacteria in Alzheimer’s disease.
They used AI to analyze the genetic information of brain receptors and structure the shape of the receptor proteins. They then predicted how specific gut metabolites would bind to the receptors. Most of the metabolites were lipids or substances similar to lipids.
The gut metabolites commonly found in patients with Alzheimer’s disease were agmatine and phenethylamine.
The study found that agmatine and phenethylamine bound to brain receptors and reduced the amount of tau protein. Tau proteins, which become tangled and twisted, are known to be involved in the pathology of Alzheimer’s disease.
Researchers have concluded that gut bacteria metabolites in Alzheimer’s patients impact the brain.
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